Immune-mediated hypothyroidism and autoimmune hemolytic anemia are the two most common immunological problems in Bouviers, although they are very rare. Immune-mediated hypothyroidism is an inherited disease, while autoimmune hemolytic anemia is not. The most common cause of autoimmune- mediated anemia is immune-mediated, although it can also be caused by toxins, infections, tumors, and other causes.